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Primary pigmented nodular adrenocortical disease (PPNAD)...

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare disease of the adrenal glands. The adrenal glands are small glands located above each kidney. The adrenals make hormones. Hormones are chemical substances formed in one organ or part of the body that travel in the blood to other body parts where they influence how that body part works. Cortisol is one of the hormones made by the adrenals. Cortisol influences body metabolism (how the body converts small molecules to large and vice versa) and can decrease inflammation. People with PPNAD have adrenal glands that make too much cortisol or make it at inappropriate times (when the body does not need it).

The Liddle’s test, or long dexamethasone suppression test, is used to evaluate adrenal gland function. See Sam's poster (PDF).

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=Display&DB=pubmed

Primary pigmented nodular adrenocortical disease (PPNAD): immunohistochemical and in situ hybridization analysis of steroidogenic enzymes in eight cases.

Department of Pathology, Tohoku University School of Medicine, Sendai, Japan.

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare but an interesting adrenocortical disorder associated with ACTH-independent hypercortisolism. We have studied eight cases of the adrenals with PPNAD by immunohistochemistry of all steroidogenic enzymes involved in cortisol biosynthesis (P-45scc, 3 beta-HSD, P-450c21, P-45017 alpha, and P-45011 beta) and also by performing in situ hybridization of P-45017 alpha in seven cases in order to localize the sites of specific steroidogenesis in this unique disorder. Immunoreactivity of all the enzymes examined was intense in almost all of the cells in adrenocortical nodules, especially the cells with abundant eosinophilic cytoplasm in all the cases examined. The internodular cortex, which demonstrated atrophy in five cases, normal appearance in two cases and hyperplasia in one case, was negative for the enzymes with an exception of 3 beta-HSD. Hybridization signals of P-45017 alpha were condensed over the nodules in in situ hybridization study, suggestive of an increased production of the enzyme itself in cortical cells of the nodules. These results may be consistent with autonomous cortisol production by the nodular cells and indicate that almost all of the cells in the nodules produce cortisol, which can also explain the presence of hypercortisolism despite small sizes of adrenals in PPNAD. Immunoreactivity of steroidogenic enzymes is observed in a small cluster of cortical cells with abundant eosinophilic cytoplasm located at the zona reticularis but not in adjacent non-nodular cortex, which may support an abnormal development of the zona reticularis as a possible pathogenesis of this disorder.

PMID: 1542635 [PubMed - indexed for MEDLINE]

 
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PMID: 8678951 [PubMed - indexed for MEDLINE]
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55: Ohara N, Takasu N, Komiya I, Takeda T, Nagasawa Y, Otsuka H, Yamada T, Hashizume K. Related Articles
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PMID: 8228470 [PubMed - indexed for MEDLINE]
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Free Full Text Carney's complex with primary pigmented nodular adrenocortical disease and spotty pigmentations.
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PMID: 8495049 [PubMed - indexed for MEDLINE]
57: Sasano H, Miyazaki S, Sawai T, Sasano N, Nagura H, Funahashi H, Aiba M, Demura H. Related Articles
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58: Travis WD, Tsokos M, Doppman JL, Nieman L, Chrousos GP, Cutler GB Jr, Loriaux DL, Norton JA. Related Articles
Abstract Primary pigmented nodular adrenocortical disease. A light and electron microscopic study of eight cases.
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PMID: 2679153 [PubMed - indexed for MEDLINE]
59: Doppman JL, Travis WD, Nieman L, Miller DL, Chrousos GP, Gomez MT, Cutler GB Jr, Loriaux DL, Norton JA. Related Articles
Abstract Cushing syndrome due to primary pigmented nodular adrenocortical disease: findings at CT and MR imaging.
Radiology. 1989 Aug;172(2):415-20.
PMID: 2748822 [PubMed - indexed for MEDLINE]
60: Grant CS, Carney JA, Carpenter PC, van Heerden JA. Related Articles
Abstract Primary pigmented nodular adrenocortical disease: diagnosis and management.
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PMID: 3787476 [PubMed - indexed for MEDLINE]
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