Saturday, November 24, 2007

Mayo Clinic Cushing's study: looking for pituitary participants

Evaluation of MRI of the Pituitary Gland and Corticotropin Releasing Hormone Stimulated Magnetic Resonance Three-Tesla Imaging in ACTH-Dependent Cushing's Disease

IRB Number : 1343-05

Trial Status: Open for Enrollment

Phase: I

Why is this study being done?

This research study is being done to find a better method of imaging to find and characterize small tumors of the pituitary gland (master hormonal gland) which cause Cushing's Disease. In many patients the tumors causing this disease are not seen or poorly seen on regular imaging. A new magnetic resonance imaging (MRI) method will be used, along with hormonal stimulation.

Who is Eligible to Participate in the Study?

Men or women 18 years of age and older diagnosed with ACTH-dependent Cushing's disease may be eligible to participate in this research study.

What is Involved With this Study?

Mayo Clinic Endocrinologists and Neuroradiologists launched a study combining state-of-the-art three-tesla (3T) MRI with stimulation of the pituitary gland using corticotropin-releasing hormone (CRH) in an attempt to better detect and characterize ACTH-producing pituitary tumors. The study will compare the sensitivity and specificity of CRH-stimulated 3T MRI with 3T MRI using standard contrast but no hormonal stimulation.

Results of this study might impact how patients with suspected pituitary lesions are managed, and might improve the outcome of neurosurgery. Participants will receive an initial endocrine evaluation to confirm their CD diagnosis. They will then have two 3T MRIs. All study-related exams and procedures will be provided at no cost to participants.

How long will the Study run?

You will be in the study for the period of time between the two MRI scans, while you are undergoing your evaluation of Cushing's disease. We will store the data indefinitely in a secure and anonymous way.

Who can I Contact for Additional Information on this Trial?

To refer an ACTH-dependent Cushing's disease patient for this research study, please contact Dr. Dana Erickson (Division of Endocrinology) at (507) 284-2784.

What is/are the Locations of this Clinical Trial?

Rochester, MN