And It's About Time There Was Some Support For Cushing's!
Lab Values G-L from tests commonly used in Cushing's Testing.
Adapted from http://www.medowbraun.com/WWAWP/WWAWP.EXE/CONNECT/emper4
| G | H | I | l |
| Test Name | Normal Values | Notes | Higher can mean: | Lower can mean: | ||||||||||||||||||||||||||||||||||||||||||||
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| Gamma-glutamyl transferase {GGT} | normal value US:
females: 1 - 70 U/L;
males: 1 - 94 U/L |
values in adult males are 25% greater than adult females | alcoholism biliary atresia cancer cancer {liver} cancer {pancreatic} cholestasis cholestasis {drug induced} cirrhosis congested liver congestive heart failure diabetes hepatic disease hepatitis hepatitis {alcoholic} hepatoma hyperthyroidism jaundice {obstructive} muscular dystrophy nephrotic syndrome neurologic disease pancreatitis primary biliary cirrhosis renal failure renal transplant sepsis systemic lupus erythematosus mononucleosis {infectious} myocardial infarction pregnancy trauma DRUGS: acetaminophen {overdose} alcohol aminosalicylic acid amitriptyline androgens antipyrine azathioprine barbiturates benzodiazepines captopril carbamazepine carbarsone cephalosporins chlorthiazide chlorpropamide clavulanic acid dapsone erythromycin estrogen ethionamide glyburide gold imipramine mercaptopurine methimazole mitoxantrone nicotinic acid nitrofurantoin penicillamine penicillin phenobarbital phenothiazines phenylbutazone phenytoin progestins propoxyphene steroids streptokinase sulfonamides sulfones sulindac tamoxifen tolbutamide |
cancer {liver} hypothyroidism DRUGS: ascorbic acid benzafibrate clofibrate fenofibrate oral contraceptives |
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| Glucose | normal value US: 70 - 110mg/100dL normal value SI: 3.9 - 6.1mmol/L |
a plasma concentration of at least 40mg/dL is necessary to maintain normal brain
function, patient should be fasting 8 hours prior to specimen collection the following depicts a fasting glucose test in a diabetic patient: >140 fasting, >200 at 1/2 hour, 1 hour, 1 1/2 hours, and 2 hours. plasma glucose concentrations greater than 180mg/dL may exceed the maximal renal tubular reabsorption rate and result in glucose in the urine. |
acanthosis nigricans acromegaly Addison's disease ataxia telangiectasis brain damage cancer {pancreatic} carcinoid syndrome congestive heart failure Cushing's disease diabetes diabetic ketoacidosis giantism glucagonoma hemochromatosis hepatic disease hyperthyroidism hypothalamic lesions nonketotic hyperglycemic coma pancreatitis pancreatitis due to mumps pancreatitis {acute} pancreatitis {chronic} pheochromocytoma renal disease somatostatinoma stroke thyrotoxicosis Wernicke's encephalopathy burns exercise {excessive} hyperglycemia hypokalemia infection myocardial infarction nonfasting specimen pregnancy seizure shock smoking stress strong emotion trauma DRUGS: acetazolamide ACTH albuterol anesthesia {general} asparaginase beta blockers caffeine calcitonin chlorthalidone corticosteroids diazoxide diuretics {loop} diuretics {thiazide} dopamine epinephrine estrogen ethacrynic acid fructose furosemide glucagon glucocorticoids glucose indomethacin isoniazid lithium MAOI morphine norepinephrine octreotide oral contraceptives phenothiazines phenytoin rifampin steroids streptozocin terbutaline theophylline thiabendazole thyroxine triamterene |
Addison's disease Beckwith syndrome cachexia cancer cancer {adrenal} cancer {gastric} erythroblastosis fetalis fructose intolerance galactosemia hepatic disease hyperinsulinism hypopituitarism hypothyroidism insulin autoimmune hypoglycemia insulinoma islet cell tumor renal glycosuria Reye's syndrome Von Gierke's disease Zetterstrom's syndrome glucagon deficiency hypoglycemia {postprandial} infant of diabetic mother ketotic hypoglycemia malnutrition poisoning prematurity DRUGS: alcohol antihistamines antitubercular drugs benzafibrate beta blockers clofibrate cyproterone disopyramide fenfluramine gemfibrozil guanethidine indomethacin insulin insulin {overdose} marijuana metformin MAOI pentamidine salicylates spironolactone sulfonylureas tromethamine |
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| Growth hormone |
|
acromegaly anorexia nervosa cirrhosis diabetes ectopic GH secretion giantism hypothalamic lesions pituitary giantism pituitary tumor renal failure exercise {excessive} hypoglycemia malnutrition starvation DRUGS: amphetamines arginine atenolol baclofen beta blockers bromocriptine clonidine corticotropin estrogen glucagon growth hormone guanfacine insulin levodopa methylphenidate metoclopramide metoprolol metyrapone nalorphine nicotinic acid oral contraceptives oxprenolol propranolol vasopressin |
Cushing's
disease hypopituitarism metastases obesity pituitarism dwarfism DRUGS: bromocriptine corticosteroids glucose phenothiazines pirenzepine probucol |
| Test Name | Normal Values | Notes | Higher can mean: | Lower can mean: |
|---|---|---|---|---|
| IGF-1 {Somatomedin C | Female: US
value {ng/dL} Preadolescent: 61 - 725 Adolescent: 113 - 450 Adult: 142 - 329 Male: US value {ng/dL} Preadolescent: 66 - 845 Adolescent: 83 - 378 Adult: 54 - 329 |
Somatomedin C is used in the diagnosis of growth hormone disorders |
acromegaly malnutrition |
anorexia diabetes Dwarfism hepatic disease hypothyroidism malnutrition |
| Insulin {serum} | normal value US: 0 - 180pmol/L | insulin is an essential hormone for the proper metabolism of blood sugar
{glucose} and maintenance of blood sugar level. an increase in blood sugar causes an increase in the secretion of insulin if the body fails to secrete and adequate amount of insulin, improper metabolism of carbohydrates and fats causes diabetes characterized by hyperglycemia and glycosuria insulin is produced in, stored, and released from the Beta cells of the pancreas actions of insulin: increases the uptake of glucose by the tissues, increases liver glycogen levels, increases synthesis of fatty acids, decreases glycogen breakdown by the liver, decreases breakdown of fatty acids into ketone bodies, promotes incorporation of amino acids into proteins, the adult pancreas secretes 25-50 U of insulin per day. |
acromegaly Cushing's disease hyperinsulinism insulinoma obesity DRUGS: corticotropin epinephrine insulin levodopa oral contraceptives steroids sulfonylureas thyroid hormones |
diabetes mellitus |
| Test Name | Normal Values | Notes | Higher can mean: | Lower can mean: |
|---|---|---|---|---|
| Luteinizing hormone {female} | normal value US: follicular 3 - 14 IU/L; luteal 2 - 14 IU/L normal value SI: follicular 3 - 14 IU/L; luteal 2 - 14 IU/L |
luteinizing hormone {LH} is secreted by the anterior lobe of the hypophysis, which stimulates develpment of the corpus luteum |
ovarian failure polycystic ovarian disease postmenopause |
amenorrhea-galactorrhea syndrome anorexia nervosa hypopituitarism DRUGS: estrogen oral contraceptives progesterone steroids testosterone |
| Lymphocyte | Lymphocyte: 20% - 40% | Addison's
disease agranulocytosis Banti's syndrome brucellosis chicken pox Crohn's disease cytomegalovirus Felty's syndrome hepatitis hyperthyroidism multiple myeloma mumps pertussis serum sickness syphilis {congenital} syphilis {secondary} thrombocytopenic purpura {idiopathic} toxoplasmosis ulcerative colitis mononucleosis {infectious} pneumonia {viral} |
AIDS anemia {aplastic} cancer congestive heart failure Cushing's disease Hodgkin's disease renal failure systemic lupus erythematosus DRUGS: corticosteroids epinephrine immunosuppressive medications |
