Current Clinical Trials
From NIH (July 12, 2008)
1 Condition: Pituitary Adenoma Intervention: 2 Condition: Pituitary Tumor Intervention: 3 Condition: Brain and Central Nervous System Tumors Interventions: Drug: temozolomide; Procedure: DNA methylation analysis; Procedure: gene expression profiling; Procedure: laboratory biomarker analysis; Procedure: protein expression analysis; Procedure: proteomic profiling 4 Condition: Brain and Central Nervous System Tumors Intervention: Drug: rosiglitazone maleate 5 Conditions: Abnormalities; Craniopharyngioma; Cushing's Syndrome; Endocrine Disease; Pituitary Neoplasm Intervention: 6 Conditions: Healthy; Pituitary Disease; Thyroid Disease Intervention: Drug: TRH (Thyrotropin Releasing Hormone) 7 Conditions: Growth Hormone Deficiency; Pituitary Tumor Intervention: 8 Conditions: Hypothalamic-Pituitary Lesions; Craniopharyngiomas Intervention: Drug: DIAZOXIDE 9 Condition: Brain and Central Nervous System Tumors Interventions: Drug: rosiglitazone maleate; Procedure: laboratory biomarker analysis 10 Conditions: Hyperthyroidism; Hypothyroidism; Pituitary Neoplasm Intervention: 11 Conditions: Acromegaly; Growth Hormone Deficiency; Pituitary Disease Interventions: Drug: Somatropin; Drug: Placebo 12 Conditions: Traumatic Brain Injury; Subarachnoid Hemorrhage; Hypopituitarism Intervention: 13 Conditions: Acromegaly; Pituitary Neoplasm Intervention: 14 Condition: Acromegaly Associated With Pituitary Gland Macroadenoma Intervention: Drug: Lanreotide autogel 15 Conditions: Hypothalamus-Pituitary-Adrenal Axis Assessement; Topical Steroid Therapy in Chronic Skin Diseases Intervention: 16 Conditions: Menopause; Hypertension Intervention: Behavioral: intermedin 17 Condition: Acromegaly Intervention: 18 Condition: Depression Interventions: Drug: Mifepristone; Drug: Placebo 19 Condition: Panhypopituitarism Intervention: Drug: Transdermal Testosterone gel 20 Conditions: Hypopituitarism; Hypogonadism; Thyroid Dysfunction; Bone Diseases, Metabolic Intervention: 21 Condition: Dwarfism, Pituitary Intervention: 22 Conditions: Dwarfism, Pituitary; Turner Syndrome Intervention: 23 Conditions: Acromegaly; Growth Hormone Deficiency Intervention: 24 Condition: Asthma Interventions: Drug: FlutiForm 250/10 ug; Drug: FlutiForm 100/10 ug; Drug: Oral Prednisone 10mg; Drug: Placebo 25 Conditions: Turner Syndrome; Renal Insufficiency, Chronic; Pituitary Diseases; Dwarfism Intervention: Drug: Somatropin (rDNA origin) 26 Condition: Psychosocial Adjustment Intervention: 27 Condition: Neurologic Disorders Intervention: 28 Conditions: Brain and Central Nervous System Tumors; Lymphoma Interventions: Procedure: cytology specimen collection procedure; Procedure: physiologic testing 29 Condition: Hypopituitarism Interventions: Other: corticotropin releasing hormone (CRH); Other: Placebo 30 Condition: Psoriasis Vulgaris Intervention: Drug: Calcipotriol plus hydrocortisone (LEO 80190) 31 Condition: Aging Intervention: Drug: anastrazole or dutasteride 32 Condition: Endocrine Diseases Intervention: 33 Condition: Cushing Syndrome Intervention: 34 Conditions: Psychotic Disorders; Depression; Depressive Disorder, Major Intervention: Drug: Mifepristone 35 Condition: Aortic Aneurysm, Abdominal Intervention: Drug: Adrenocorticotrophic hormone 36 Condition: Brain and Central Nervous System Tumors Interventions: Drug: antineoplaston A10; Drug: antineoplaston AS2-1 37 Conditions: Kallmann Syndrome; Idiopathic Hypogonadotropic Hypogonadism Intervention: Drug: gonadotropin releasing hormone (GnRH) 38 Conditions: Aging; Hypogonadism; Andropause Interventions: Drug: Anastrozole; Drug: Testosterone Gel 39 Condition: Adrenal Insufficency Intervention: 40 Condition: Secondary Adrenal Insuffisency Intervention: 41 Condition: Acromegaly Intervention: Drug: Octreotide acetate and cabergoline 42 Condition: Hypogonadism Intervention: Drug: Ketoconazole, Dexamethesone, Androgel,GnRH 43 Condition: Atopic Dermatitis Intervention: Drug: Fluticasone propionate 0.05% lotion 44 Conditions: Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm Intervention: 45 Condition: Hypogonadism Interventions: Drug: MPP10, testosterone; Drug: Testosterone 46 Conditions: Hypogonadotropic Hypogonadism; Amenorrhea; Kallman's Syndrome Interventions: Drug: GnRH; Device: Mini-infusion pump 47 Condition: Heart Arrest Intervention: Drug: Hydrocortisone 48 Condition: Premenopause Interventions: Drug: Estradiol steroid infusion; Drug: Progesterone steroid infusion 49 Conditions: Schizophrenia; Hyperprolactinemia Intervention: Drug: Bromocriptin 50 Condition: Growth Hormone Deficiency Intervention: Drug: growth hormone administration for 6 months
51 Conditions: Acromegaly; Growth Hormone Deficiency Intervention: 52 Condition: Acromegaly Interventions: Drug: C2L-OCT-01 PR, 10 or 20 mg; Drug: C2L-OCT-01 PR, 20 mg 53 Condition: Cushing's Syndrome Intervention: Drug: mifepristone 54 Condition: Acromegaly Intervention: Drug: furosemide 55 Conditions: Hypogonadism; Kallmann Syndrome; Puberty, Delayed; Puberty, Precocious; Hypothalamic Amenorrhea; Anosmia Intervention: 56 Condition: Major Depressive Disorder Interventions: Drug: DEX-CRF stimulation test; Behavioral: Psychosocial stress induction; Procedure: Brain imaging of sad mood , self-reference, reward; Behavioral: Acoustic startle 57 Conditions: Cushing's Syndrome; Insulin Resistance Intervention: Procedure: Surgery 58 Condition: Healthy Intervention: 59 Condition: Adrenal Hyperplasia, Congenital Intervention: Drug: dexamethasone 60 Condition: Hypogonadism Interventions: Drug: gonadotropin releasing hormone; Drug: leuprolide 61 Condition: Traumatic Brain Injury Intervention: 62 Condition: Cushing's Syndrome Intervention: 63 Conditions: Insulin Resistance; Hyperglycemia Intervention: Drug: insulin-like growth factor I 64 Condition: Cushing's Disease Intervention: Drug: Pasireotide 65 Condition: Histiocytosis, Langerhans-Cell Intervention: 66 Conditions: Polycystic Ovary Syndrome; Obstructive Sleep Apnea Interventions: Device: continuous positive airway pressure (CPAP); Drug: depot leuprolide plus estrogen/progestin replacement; Drug: pioglitazone 67 Conditions: Breast Neoplasms; Fibrocystic Disease of Breast; Mammaplasty Intervention: 68 Condition: Hypogonadism Intervention: Drug: Gonadotropin Releasing Hormone (GnRH) 69 Condition: Depression Intervention: Drug: Testosterone 70 Condition: Bipolar Depression Intervention: Drug: mifepristone (RU-486) 71 Conditions: Cocaine Dependence; Alcohol Dependence Interventions: Drug: Prazosin; Drug: placebo 72 Condition: Obesity Intervention: 73 Conditions: Amenorrhea; Hypogonadotropic Hypogonadism; Kallmann's Syndrome Intervention: Procedure: Frequent baseline blood sampling 74 Condition: Insulin-Like Growth Factor-1 Deficiency Interventions: Drug: somatropin; Drug: mecasermin and somatropin; Drug: mecasermin and somatropin; Drug: mecasermin and somatropin 75 Condition: Adrenal Insufficiency Intervention: 76 Condition: Healthy Interventions: Drug: estetrol; Drug: estetrol; Drug: estetrol and desogestrel; Drug: estetrol and progesterone 77 Condition: Healthy Intervention: Drug: Ethylvinyl Acetate (EVA) Vaginal Ring Delivery System 78 Conditions: Cocaine Dependent; Alcohol Dependent Interventions: Drug: Guanfacine; Drug: Placebo 79 Conditions: Endometriosis; Pelvic Pain; Healthy; Tubal Ligation Intervention: 80 Conditions: Anovulation; FHA; Eumenorrhea Intervention: 81 Condition: Type 2 Diabetes, Insulin Requiring Interventions: Other: oral ethanol, overnight; Other: IV ethanol; Other: soda water; Other: soda water 82 Condition: Cushing's Syndrome Intervention: Drug: Mifepristone 83 Condition: Graft vs Host Disease Intervention: Drug: Dexamethasone 0.01% Solution 84 Conditions: Thyroid Cancer; Differentiated Thyroid Carcinoma Intervention: Drug: Lithium Carbonate 85 Condition: Cocaine Dependence Interventions: Drug: Progesterone; Drug: Placebo 86 Condition: Acromegaly Intervention: 87 Conditions: Acromegaly; Diabetes; Insulin Resistance; Impaired Glucose Tolerance Intervention: 88 Condition: Panhypopituitarism Intervention: Drug: Transdermal Testosterone Gel 89 Condition: Acromegaly Intervention: Drug: Alesse 90 Conditions: Growth Hormone Deficiency; Septo-Optic Dysplasia; Hypopituitarism Intervention: Drug: Nutropin AQ 91 Condition: Acromegaly Intervention: 92 Condition: Hypopituitarism Intervention: Drug: TheraDerm 93 Conditions: Hyperprolactinemia; Insulin Resistance Intervention: Drug: Cabergoline 94 Condition: Acromegaly Intervention: Drug: Somatuline Autogel 95 Condition: Nephrogenic Diabetes Insipidus Interventions: Drug: sildenafil; Drug: calcitonin; Drug: hydrochlorothiazide/amiloride; Drug: indomethacin; Drug: Placebo for sildenafil; Drug: placebo for calcitonin 96 Condition: Acromegaly Intervention: 97 Conditions: Hyperprolactinemia; Endometriosis Intervention: Procedure: ENDOMETRIAL BIOPSY 98 Conditions: Acromegaly; Heart Failure; Hypertrophy, Left Ventricular Intervention: Drug: pegvisomant 99 Conditions: Hyperprolactinemia; Weight Gain; Dyslipidemia Intervention: Drug: Abilify (aripiprazole) 100 Condition: Acromegaly Intervention: Drug: Lanreotide Autogel 120 mg
101 Condition: Acromegaly Intervention: Drug: C2L-OCT-01 PR 30 mg 102 Condition: Acromegaly Interventions: Drug: Sandostatin LAR; Drug: Sandostatin LAR 103 Conditions: Acromegaly; Growth Hormone; Insulin Resistance Intervention: Procedure: Transsphenoidal adenomectomy 104 Conditions: Acromegaly; Insulin Resistance; Impaired Glucose Tolerance Interventions: Drug: Pegvisomant; Drug: Somatostatin analog (Lanreotid or Octreotid) 105 Conditions: Hypopituitarism; Hypogonadism; Growth Hormone Deficiency Interventions: Drug: Testosterone plus somatropin; Drug: testosterone 106 Condition: Acromegaly Intervention: Drug: Pasireotide
From NIH (7/10/2008)
1 Conditions: Adrenal Tumors; Adrenal Malignancies; Abnormal Hormonal Secretions; Electrolytes Abnormalities Intervention: Other: Imaging, Adrenal acans 2 Conditions: Cardiopulmonary Arrest; Cardiac Arrest Interventions: Drug: Vasopressin; Drug: Epinephrine 3 Condition: Adrenal Function Intervention: Drug: megestrol acetate 4 Condition: Congenital Disorders Intervention: Drug: Epinephrine 5 Condition: Adrenal Insufficiency Intervention: 6 Conditions: Digestive Diseases; Adrenal Insufficiency; Gastrointestinal Bleeding; Variceal Bleeding; Acute Pancreatitis Intervention: 7 Conditions: Lung Cancer; Adrenal Insufficiency Intervention: 8 Conditions: Sepsis; Adrenal Insufficiency Intervention: Drug: Fludrocortisone 9 Conditions: Congenital Adrenal Hyperplasia; 21-Hydroxylase Deficiency; Adrenogenital Syndrome Intervention: Drug: Chronocort for the treatment of CAH 10 Condition: Cardiac Arrest Interventions: Drug: Vasopressin; Drug: Adrenaline 11 Conditions: Adrenal Tumors; Adrenocortical Carcinoma; Cushing Syndrome; Conn Syndrome; Pheochromocytoma Intervention: 12 Conditions: Addison Disease; Hypoaldosteronism Intervention: Procedure: Laparoscopic hand-assisted donor nephrectomy 13 Condition: Adrenal Gland Neoplasm Intervention: 14 Condition: Adrenal Hyperplasia, Congenital Intervention: Drug: Hydrocortisone sodium acetate 15 Conditions: Adrenal Hyperplasia, Congenital; Psychosexual Development; Sexual Development; Intersex; Congenital Adrenal Hyperplasia Intervention: Other: Interview 16 Condition: Adrenal Hyperplasia, Congenital Intervention: Drug: dexamethasone 17 Conditions: Hypothalamus-Pituitary-Adrenal Axis Assessement; Topical Steroid Therapy in Chronic Skin Diseases Intervention: 18 Conditions: Adrenal Tumor; Adrenocortical Carcinoma Intervention: Drug: 123I-Iodometomidate 19 Conditions: Pregnancy; Pain Interventions: Drug: adrenalin; Drug: placebo 20 Condition: Cirrhosis With Ascites Interventions: Drug: hydrocortisone; Drug: dextrose solution 5% 21 Condition: Type 1 Diabetes Interventions: Drug: epinephrine; Drug: epinephrine 22 Conditions: Disorders of Sex Development; Congenital Adrenal Hyperplasia; Congenital Adrenal Hypoplasia; Adrenal Insufficiency; Mineralocorticoid Deficiency Intervention: Procedure: blood drawing 23 Condition: Adrenal Hyperplasia, Congenital Intervention: 24 Condition: Adrenocortical Carcinoma Interventions: Drug: antineoplaston A10; Drug: antineoplaston AS2-1 25 Condition: Cushing's Syndrome Intervention: Drug: Mifepristone 26 Condition: Type 1 Diabetes Interventions: Drug: epinephrine; Drug: epinephrine 27 Condition: Adrenal Hyperplasia, Congenital Intervention: 28 Conditions: Excess Androgen; Congenital Adrenal Hyperplasia (CAH); Familial Male-Limited Precocious Puberty (FMPP) Intervention: 29 Condition: Asthma Interventions: Drug: FlutiForm 250/10 ug; Drug: FlutiForm 100/10 ug; Drug: Oral Prednisone 10mg; Drug: Placebo 30 Condition: Adrenal Insufficency Intervention: 31 Condition: Secondary Adrenal Insuffisency Intervention: 32 Condition: Adrenal Sufficiency Intervention: 33 Conditions: Autoimmune Disease; Congenital Adrenal Hyperplasia; Healthy; Mental Disorder Diagnosed in Childhood; Neurologic Manifestations Intervention: 34 Conditions: Hypertension; Adrenal Aldosterone-Producing Adenoma Intervention: 35 Condition: Alopecia Areata Intervention: Drug: Triamcinolone Acetonide 10 mg/mL 36 Condition: Anorexia Nervosa Intervention: Drug: DHEA + Hormone replacement therapy (estrogen/progestin) 37 Conditions: Adrenocortical Carcinoma; Neuroblastoma; Precancerous/Nonmalignant Condition Interventions: Procedure: computed tomography; Procedure: magnetic resonance imaging 38 Conditions: Anesthesia; Enteral Nutrition Interventions: Procedure: bupivacaine with epinephrine (mid and upper abdomen); Procedure: bupivacaine with epinephrine (transversus abdominis plane) 39 Condition: Acute Lung Injury Interventions: Drug: Diuresis (furosemide) part I; Other: Fluid Bolus (crystalloid or albumin); Other: Fluid Bolus (crystalloid or albumin); Drug: Vasopressors (Norepinephrine, Vasopressin, Phenylephrine, Epinephrine); Drug: Vasopressors (Norepinephrine, Vasopressin, Phenylephrine, Epinephrine); Drug: Dobutamine; Drug: Dobutamine; Other: Concentrate all drips and nutrition; Drug: Diuresis (furosemide) part II; Procedure: Dialysis 40 Condition: Psoriasis Vulgaris Intervention: Drug: Calcipotriol plus hydrocortisone (LEO 80190) 41 Condition: Depression Interventions: Drug: Mifepristone; Drug: Placebo 42 Conditions: Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm Intervention: 43 Condition: 21-Hydroxylase Deficiency Intervention: Procedure: Hydrocortisone withdrawal 44 Condition: Osteoarthritis of the Knee Interventions: Drug: ropivacaine; Drug: adrenaline; Drug: ketorolac; Drug: morphine; Drug: fentanyl; Drug: bupivacaine 45 Condition: Cardiac Surgery Interventions: Drug: etomidate; Drug: propofol 46 Condition: Psychosocial Adjustment Intervention: 47 Conditions: Neoplasms; Heart Diseases; Adrenal Cortex Diseases Intervention: Behavioral: Case management 48 Conditions: Pseudohermaphroditism; Congenital Adrenal Hyperplasia; Hypertension Intervention: Procedure: blood drawing 49 Condition: Pain, Postoperative Intervention: Drug: .5% bupivacaine with epinephrine 50 Condition: Cushing's Syndrome Intervention: Drug: mifepristone
From NIH (7/8/2008)
1 Condition: Cushing's Syndrome Intervention: Drug: Mifepristone 2 Condition: Cushing's Syndrome Intervention: 3 Condition: Cushing's Syndrome Intervention: Drug: mifepristone 4 Condition: Cushing's Syndrome Intervention: 5 Condition: Cushing's Syndrome Intervention: 6 Condition: Cushing Syndrome Intervention: 7 Condition: Cushing Syndrome Intervention: 8 Condition: Cushing Disease Intervention: Drug: Pasireotide 9 Conditions: Cushing's Syndrome; Healthy Intervention: 10 Conditions: Cushing's Syndrome; Insulin Resistance Intervention: Procedure: Surgery 11 Condition: Cushing's Syndrome Intervention: 12 Condition: Cushing's Disease Intervention: Drug: Pasireotide 13 Condition: Cushing's Syndrome Intervention: 14 Condition: Cushing's Syndrome Intervention: Drug: SOM230 s.c. 15 Condition: Cushing Syndrome Intervention: 16 Conditions: Adrenal Gland Hyperfunction; Adrenal Gland Hypofunction; Cushing's Syndrome; Healthy Intervention: Drug: Ovine Corticotropin-Releasing Hormone (oCRH) 17 Conditions: Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm Intervention: 18 Conditions: Abnormalities; Craniopharyngioma; Cushing's Syndrome; Endocrine Disease; Pituitary Neoplasm Intervention: 19 Condition: Brain and Central Nervous System Tumors Interventions: Drug: rosiglitazone maleate; Procedure: laboratory biomarker analysis 20 Conditions: Adrenocortical Carcinoma; Cushing's Syndrome Intervention: 21 Conditions: Adrenal Gland Hyperfunction; Cardiovascular Disease; Involutional Depression Intervention: 22 Conditions: Adrenal Tumors; Adrenocortical Carcinoma; Cushing Syndrome; Conn Syndrome; Pheochromocytoma Intervention: 23 Conditions: Mood Disorder; Neurobehavioral Manifestation; Healthy Intervention: 24 Conditions: Healthy; Involutional Depression Intervention: 25 Condition: Adrenal Gland Neoplasm Intervention: 26 Condition: Addison Syndrome Intervention: Drug: hydrocortisone substitution therapy versus withdrawal 27 Condition: Brain and Central Nervous System Tumors Intervention: Drug: rosiglitazone maleate 28 Condition: Mood Disorder Intervention: 29 Condition: Diabetes Mellitus, Type 2 Interventions: Other: Pharmacist collaboration in diabetes care; Other: Usual care 30 Condition: Systemic Lupus Erythematosus Intervention: Drug: rhuMAb IFNalpha 31 Condition: Lupus Nephritis Interventions: Drug: Etanercept; Drug: Lupus Treatment
Baseline Studies to Evaluate Consequences of Low Testosterone and
To Receive Testosterone Replacement for 2 Months.
Dr. Theodore Friedman from Charles R. Drew University, Division of Endocrinology is currently seeking patients to participate in a research study of pituitary dysfunction.
Ages 18-55.
To Undergo Baseline Studies to Evaluate Consequences of Low Testosterone and
To Receive Testosterone Replacement for 2 Months.
Subjects Will Be Compensated.
Contact:
Dr. Friedman or Dr. Zuckerbraun
study@goodhormonehealth.com
More info .
Recruiting men with pituitary disease who have testosterone
and growth hormone deficiencies.
Recruiting men with pituitary disease who have testosterone
and growth hormone deficiencies.
Both testosterone and growth hormone individually improve bone density in men
who have deficiencies of these hormones. The purpose of this research study is
to determine if the combination of testosterone and growth hormone improves bone
structure more than testosterone alone.
Thirteen outpatient visits over a 2-year period are required. Bone structure
will be evaluated three times (at the beginning, after 12 months, and after 24
months). Three kinds of tests will be performed: DEXA, MRI and p-QCT. All three
are non-invasive tests of bone quality and low risk.
By participating in this study you will learn more about the health of your
bones and other aspects of your health. Reports will be provided to you and to
any physician you wish. The study covers the cost of all study procedures and
medications.
Study Criteria:
Be male and over 18 years of age
Have documented pituitary disease
Be deficient in testosterone and growth hormone
Have not taken growth hormone or testosterone within the past two years
Contact:
Helen Peachey, RN, Research Coordinator
peacheyh@mail.med.upenn.edu
Profile Page: University of Pennsylvania Health System,
Philadelphia, PA
