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Current Clinical Trials

Cushing's, updated June 4, 2011

Rank Status Study
1 Recruiting Safety and Efficacy of LCI699 in Cushing's Disease Patients
Condition: Cushing Disease
Intervention: Drug: LCI699
2 Recruiting Preoperative Bexarotene Treatment for Cushing's Disease
Condition: Cushing's Disease
Intervention: Drug: Bexarotene
3 Recruiting Rosiglitazone in Treating Patients With Newly Diagnosed ACTH-Secreting Pituitary Tumor (Cushing Disease)
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: rosiglitazone maleate; Other: laboratory biomarker analysis
4 Unknown Study of Depression, Peptides, and Steroids in Cushing's Syndrome
Condition: Cushing's Syndrome
Intervention:
5 Recruiting Examination of Brain Serotonin Receptors in Patients With Mood Disorders
Conditions: Mood Disorder; Bipolar Disorder; Depression
Intervention:
6 Recruiting An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
Conditions: Abnormalities; Craniopharyngioma; Cushing's Syndrome; Endocrine Disease; Pituitary Neoplasm
Intervention:
7 Recruiting Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion
Condition: Cushing's Syndrome
Intervention: Drug: Mifepristone
8 Recruiting Anesthesia Management of Retroperitoneal Adrenalectomies
Condition: Adrenal Tumors
Intervention:
9 Recruiting Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
Conditions: Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm
Intervention:
10 Recruiting New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome
Condition: Cushing Syndrome
Intervention:
11 Recruiting Adolescence, Puberty, and Emotion Regulation
Conditions: Mood Disorder; Neurobehavioral Manifestation; Healthy
Intervention:
12 Recruiting Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome
Conditions: Cushing's Syndrome; Insulin Resistance
Intervention: Procedure: Surgery
13 Recruiting Study of Adrenal Gland Tumors
Condition: Adrenal Gland Neoplasm
Intervention:
14 Not yet recruiting Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome
Condition: Adrenal Tumour With Mild Hypercortisolism
Intervention: Procedure: Adrenalectomy
15 Recruiting Assessing Fertility Potential in Female Cancer Survivors
Condition: History of Cancer
Intervention:
16 Recruiting Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin
Conditions: Pancreatic Neoplasm; Pituitary Neoplasm; Nelson Syndrome; Ectopic ACTH Syndrome
Intervention: Drug: Pasireotide LAR
17 Recruiting Adrenal Tumors - Pathogenesis and Therapy
Conditions: Adrenal Tumors; Adrenocortical Carcinoma; Cushing Syndrome; Conn Syndrome; Pheochromocytoma
Intervention:
18 Recruiting Prevalence of Pituitary Incidentaloma in Relatives of Patients With Pituitary Adenoma
Condition: Pituitary Tumor
Intervention:
19 Recruiting Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study)
Conditions: Neutropenia; Infection
Interventions: Drug: Standard antimicrobial therapy; Biological: Granulocyte transfusions; Drug: G-CFS/dexamethasone; Device: Apheresis machine

Adrenal, updated June 6, 2011

Rank Status Study
1 Recruiting Trial of Vasopressin and Epinephrine to Epinephrine Only for In-Hospital Pediatric Cardiopulmonary Resuscitation
Conditions: Cardiopulmonary Arrest; Cardiac Arrest
Interventions: Drug: Vasopressin; Drug: Epinephrine
2 Recruiting Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment
Condition: Adrenal Gland Hypofunction
Interventions: Procedure: adrenal insufficiency testing; Drug: prednisone
3 Recruiting The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine
Condition: Spinal Anesthesia
Interventions: Drug: Placebo; Drug: epinephrine 25; Drug: Epinephrine 50; Drug: epinephrine 100; Drug: Epi 200
4 Recruiting SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.
Condition: Hyperaldosteronism
Intervention: Other: Ct-scan or adrenal vein sampling
5 Not yet recruiting Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus Surgery
Conditions: Hypertension; Hypotension; Tachycardia; Bradycardia; Arrhythmia
Interventions: Drug: Epinephrin (Intranasal injection); Drug: Epinephrin (Topical administration)
6 Recruiting Adrenal Insufficiency in Septic Shock
Conditions: Septic Shock; Acute Adrenal Insufficiency
Intervention: Drug: Corticosteroid
7 Recruiting Performance of 18F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in the Diagnosis of Indeterminate Adrenal Tumors on Conventional Imaging: A French Prospective Multicentric Study
Condition: Adrenal Gland Neoplasms
Intervention: Other: FDG-PET scan
8 Unknown Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency
Condition: Adrenal Insufficiency
Intervention:
9 Recruiting Adrenal Function in Critical Illness
Condition: Adrenal Insufficiency
Intervention:
10 Recruiting Adrenal Vein Sampling International Study (AVIS Study)
Condition: Hyperaldosteronism
Intervention:
11 Recruiting Epinephrine Inhalation Aerosol USP: For Evaluation Of Efficacy And Safety In Asthma Patients
Condition: Asthma
Interventions: Drug: Epinephrine inhalation aerosol; Drug: Placebo; Drug: epinephrine inhalation aerosol
12 Unknown Adrenal Insufficiency in Critical Emergencies in Digestive Diseases
Conditions: Digestive Diseases; Adrenal Insufficiency; Gastrointestinal Bleeding; Variceal Bleeding; Acute Pancreatitis
Intervention:
13 Not yet recruiting Prevalence Study of Adrenal Suppression After Corticosteroids During Chemotherapy.
Condition: Adrenal Suppression
Intervention: Other: Prevalence study only, no study intervention
14 Recruiting Adrenal Hyperplasia Among Young People With PCOS
Conditions: Adrenal Hyperplasia; Polycystic Ovarian Syndrome; Oligomenorrhea; Obesity; Hyperandrogenism
Intervention:
15 Recruiting Low-Dose Epinephrine Infusion Tests in Adolescent and Pediatric Patients
Condition: Congenital Disorders
Intervention: Drug: Epinephrine
16 Recruiting Evaluation of Molecular Markers in Adrenal Tumors
Condition: Adrenal Gland Neoplasms
Intervention:
17 Unknown Adrenal Function After Living Kidney Donation
Conditions: Addison Disease; Hypoaldosteronism
Intervention: Procedure: Laparoscopic hand-assisted donor nephrectomy
18 Recruiting Adrenal Tumors - Pathogenesis and Therapy
Conditions: Adrenal Tumors; Adrenocortical Carcinoma; Cushing Syndrome; Conn Syndrome; Pheochromocytoma
Intervention:
19 Not yet recruiting A Pilot Study of F-18 Paclitaxel (FPAC) PET for Evaluating Drug Delivery of Solid Tumors in Breast, Lung, Renal, and Adrenal Cancers
Conditions: Breast Cancer; Lung Cancer; Renal Cancer; Adrenal Cancer
Intervention: Drug: F-18 Paclitaxel (FPAC)
20 Not yet recruiting The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery
Condition: Chronic Sinusitis
Interventions: Drug: 1% lidocaine with 1:100,000 adrenaline; Drug: 1% lidocaine with 1:200,000 adrenaline

21 Recruiting Study of Intracameral Adrenaline for Pupil Dilation Without Topical Mydriatics in Refractive Cataract Surgery
Condition: Cataract
Intervention: Drug: adrenalin
22 Recruiting Study of Adrenal Gland Tumors
Condition: Adrenal Gland Neoplasm
Intervention:
23 Recruiting The Effects of Epinephrine in Endotoxemia in Normal Volunteers
Condition: Immune System
Interventions: Biological: Endotoxin, Lipopolysaccharide, LPS; Biological: Endotoxin, Lipopolysaccharide, LPS /Epinephrine
24 Unknown Does Topical Steroid Treatment Impair the Adrenal Function?
Conditions: Hypothalamus-Pituitary-Adrenal Axis Assessement; Topical Steroid Therapy in Chronic Skin Diseases
Intervention:
25 Recruiting Combination Local Anesthetics
Condition: Perioperative Pain
Interventions: Drug: 1% Lidocaine with Epinephrine; Drug: 0.25% Bupivacaine with epinephrine; Drug: 1% Lidocaine + 0.25% Bupivacaine with Epinephrine; Drug: 2% Lidocaine + 0.5% Bupivacaine with epinephrine
26 Recruiting Study Comparing Peri-articular Injection of Bupivacaine With and Without Epinephrine
Condition: Osteoarthritis
Interventions: Procedure: Peri-articular injection of marcaine/epinephrine; Procedure: Peri-articular injection of marcaine alone
27 Not yet recruiting Gluing Lacerations Utilizing Epinephrine
Condition: Lacerations
Intervention: Drug: LET - Lidocaine Epinephrine Tetracaine
28 Recruiting Use of Local Analgesia With Epinephrine During Total Hip Arthroplasty (THA)
Condition: Arthroplasty, Replacement, Hip
Intervention: Drug: ropivacaine, physical serum and adrenalin
29 Recruiting Relative Adrenal Insufficiency in Preterm Very Low Birth Weight Infants With Shock
Condition: Adrenal Insufficiency
Intervention:
30 Unknown Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function
Condition: Cirrhosis With Ascites
Interventions: Drug: hydrocortisone; Drug: dextrose solution 5%
31 Recruiting Bronchiolitis, Optimal Treatment in Infants and Prognosis
Condition: Bronchiolitis
Interventions: Drug: Racemic adrenaline; Drug: Isotonic saline
32 Recruiting RAD001 in Pheochromocytoma or Nonfunctioning Carcinoid
Conditions: Pheochromocytoma; Extra-Adrenal Paraganglioma; Non-functioning Carcinoid
Intervention: Drug: RAD001
33 Not yet recruiting Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q4
Condition: Type 1 Diabetes
Intervention: Drug: epinephrine
34 Recruiting Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation
Condition: Hypotension After Reperfusion in Liver Transplantation
Interventions: Drug: phenylephrine; Drug: epinephrine; Drug: placebo control
35 Recruiting Safety Study Evaluating the Adrenal Suppression Potential of Product 0405 in Pediatric Subjects With Atopic Dermatitis
Condition: Atopic Dermatitis
Intervention: Drug: Product 0405
36 Recruiting Merits of Continuous Paravertebral Block in the Management of Renal/Adrenal Surgery by Laparotomy
Condition: Patient Scheduled for Renal and/or Adrenal Surgery
Intervention: Procedure: Continuous Paravertebral block
37 Not yet recruiting Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome
Condition: Adrenal Tumour With Mild Hypercortisolism
Intervention: Procedure: Adrenalectomy
38 Unknown Role of the Protein Osteoprotegerin in the Bone Health of Women With Congenital Adrenal Hyperplasia
Condition: Adrenal Hyperplasia, Congenital
Intervention:
39 Recruiting Gene Polymorphisms Influencing Steroid Synthesis and Action
Conditions: Disorders of Sex Development; Congenital Adrenal Hyperplasia; Congenital Adrenal Hypoplasia; Adrenal Insufficiency; Mineralocorticoid Deficiency; Intersex
Intervention:
40 Recruiting Adrenal Function and Use of Intralesional Triamcinolone Acetonide 10 mg/mL (Kenalog-10) in Patients With Alopecia Areata
Condition: Alopecia Areata
Intervention: Drug: Triamcinolone Acetonide 10 mg/mL (Kenalog-10)

Pituitary, updated June 5, 2011

Rank

Status Study
1 Recruiting Prevalence of Pituitary Incidentaloma in Relatives of Patients With Pituitary Adenoma
Condition: Pituitary Tumor
Intervention:
2 Not yet recruiting Evaluate the Efficacy and Safety of Pasireotide LAR on the Treatment of Patients With Clinically Non-Functioning Pituitary Adenoma
Condition: Nonfunctioning Pituitary Tumor
Intervention: Drug: Pasireotide LAR
3 Recruiting Pituitary Tumor Surveillance: Pathogenic Correlation
Condition: Pituitary Tumor
Intervention:
4 Unknown Measurement of Pituitary Volume and Hormonal Changes in Patients With Post-Traumatic Stress Disorder
Condition: Posttraumatic Stress Disorder
Interventions: Procedure: MRI of the pituitary; Procedure: DEX/CRH test
5 Recruiting Temozolomide in Treating Patients With Invasive Pituitary Tumors
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: temozolomide; Genetic: DNA methylation analysis; Genetic: microarray analysis; Genetic: protein expression analysis; Genetic: proteomic profiling; Other: laboratory biomarker analysis
6 Recruiting An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
Conditions: Abnormalities; Craniopharyngioma; Cushing's Syndrome; Endocrine Disease; Pituitary Neoplasm
Intervention:
7 Recruiting Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities
Conditions: Healthy; Pituitary Disease; Thyroid Disease
Intervention: Drug: TRH (Thyrotropin Releasing Hormone)
8 Recruiting The Diagnostic Accuracy of the Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and the Hypothalamic-Pituitary-Adrenal Axis
Conditions: Adult Growth Hormone Deficiency; Hypothalamic-pituitary Disorders
Interventions: Procedure: Glucagon stimulation test and insulin tolerance test; Procedure: glucagon stimulation test and insulin tolerance test
9 Recruiting Proton Radiation Therapy for Pituitary Adenoma
Condition: Pituitary Adenoma
Intervention: Radiation: Proton Radiation Therapy
10 Recruiting Ante-hypophyseal Dysfunctions in Children Following Moderate to Severe Traumatic Brain Injuries
Condition: Moderate to Severe Traumatic Brain Injury
Intervention: Other: Biological and behavioral explorations
11 Recruiting Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard Therapy
Conditions: Adenoma; Prolactinoma
Intervention: Drug: Lapatinib
12 Not yet recruiting To Describe the Effect of rhLH Supplementation in Women With Hyporesponse to rhFSH After Pituitary Downregulation
Condition: Infertility
Intervention: Drug: Luveris
13 Recruiting The Effect of Monoclonal Vascular Endothelial Growth Factor (VEGF) Antibody (Bevacizumab) on Pituitary Function
Conditions: Colorectal Cancer; Lung Cancer; Breast Cancer; Glioblastoma
Intervention:
14 Recruiting Anterior Pituitary Hormone Replacement in Traumatic Brain Injury
Conditions: Growth Hormone Deficiency; Traumatic Brain Injury
Interventions: Drug: Human Growth Hormone; Drug: Placebo
15 Recruiting Rosiglitazone in Treating Patients With Newly Diagnosed ACTH-Secreting Pituitary Tumor (Cushing Disease)
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: rosiglitazone maleate; Other: laboratory biomarker analysis
16 Recruiting Evaluation of Patients With Thyroid Disorders
Conditions: Hyperthyroidism; Hypothyroidism; Pituitary Neoplasm
Intervention:
17 Recruiting Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency
Conditions: Acromegaly; Growth Hormone Deficiency; Pituitary Disease
Interventions: Drug: Somatropin; Drug: Placebo
18 Unknown Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)
Conditions: Traumatic Brain Injury; Subarachnoid Hemorrhage; Hypopituitarism
Intervention:
19 Recruiting The Treatment and Natural History of Acromegaly
Conditions: Acromegaly; Pituitary Neoplasm
Intervention:
20 Recruiting Barrow Nasal Inventory Survey
Condition: Pituitary Tumors
Intervention:

Rank Status Study
21 Recruiting VRS-317 in Adult Subjects With Growth Hormone Deficiency
Condition: Growth Hormone Deficiency
Intervention: Drug: VRS-317
22 Recruiting Age-related Variability of the Efficacy and Tolerability of Alternative Pituitary Suppression Regimens in ART
Condition: Infertility
Intervention: Drug: hFSH(Fostimon)
23 Unknown Does Topical Steroid Treatment Impair the Adrenal Function?
Conditions: Hypothalamus-Pituitary-Adrenal Axis Assessement; Topical Steroid Therapy in Chronic Skin Diseases
Intervention:
24 Recruiting Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major Depression
Condition: Major Depression
Intervention: Drug: SSRI; SNRI; TCA
25 Recruiting Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin
Conditions: Pancreatic Neoplasm; Pituitary Neoplasm; Nelson Syndrome; Ectopic ACTH Syndrome
Intervention: Drug: Pasireotide LAR
26 Unknown Pituitary Derived-Intermedin is an Estrogen-Modulated Factor for Reducing Blood Pressure
Conditions: Menopause; Hypertension
Intervention: Behavioral: intermedin
27 Recruiting Adult Growth Hormone Deficiency and Cardiovascular Risk
Condition: Growth Hormone Deficiency
Interventions: Procedure: Blood draws; Drug: Growth hormone releasing hormone (GHRH) and arginine; Procedure: Carotid ultrasound; Procedure: MRI; Procedure: Endothelial cell biopsy
28 Recruiting Quetiapine Prolong, Escitalopram and Hypothalamic-pituitary-adrenocortical (HPA) Axis Activity in Depressed Patients
Condition: Major Depression
Interventions: Drug: quetiapine; Drug: escitalopram
29 Recruiting Stress, Hypothalamic-Pituitary-Adrenal (HPA) Dysfunction, and Relapse in Alcoholism
Condition: Alcohol Dependence
Intervention:
30 Recruiting A Comparative Study of Global 12 Lead Electroencephalogram to Frontal SedlineTM Electroencephalogram
Conditions: Craniotomy; Transphenoidal Pituitary Resection
Intervention:
31 Recruiting Genetics of Endocrine Tumours
Condition: Acromegaly
Intervention:
32 Unknown Testosterone Gel Applied to Women With Pituitary Gland Problems
Condition: Panhypopituitarism
Intervention: Drug: Transdermal Testosterone gel
33 Recruiting Lanreotide as Primary Treatment for Acromegalic Patients With Pituitary Gland Macroadenoma
Condition: Acromegaly
Intervention: Drug: Lanreotide autogel 120 mg
34 Recruiting Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors
Conditions: Hypopituitarism; Hypogonadism; Thyroid Dysfunction; Bone Diseases, Metabolic
Intervention:
35 Recruiting A Study Examining the Peri- and Post-operative Dynamics of the Growth Hormone (GH) - IGF-1 Axis in Subjects With Acromegaly During the First Year After Surgical Resection
Condition: Acromegaly
Intervention: Other: OGTT
36 Recruiting Clinical and Biological Characteristics of Psychotic Depression
Conditions: Depression; Psychotic Disorders; Depressive Disorder, Major
Intervention:
37 Recruiting Efficacy and Safety of Pasireotide Long Acting Release (LAR) Versus Octreotide LAR or Lanreotide Autogel (ATG) in Patients With Inadequately Controlled Acromegaly
Condition: Acromegaly
Interventions: Drug: Pasireotide (SOM230); Drug: octreotide LAR 30mg or lanreotide ATG 120mg
38 Recruiting Single Dose FSH-GEX™ in Healthy Volunteers
Condition: Female Infertility
Interventions: Drug: FSH-GEX™; Drug: Comparator 1; Drug: Comparator 2; Drug: Placebo
39 Recruiting Endocrine and Psychological Evaluation of Adopted Children
Condition: Psychosocial Adjustment
Intervention:
40 Recruiting Safety and Efficacy of LCI699 in Cushing's Disease Patients
Condition: Cushing Disease
Intervention: Drug: LCI699

Dr. Theodore Friedman from Charles R. Drew University, Division of Endocrinology is currently seeking patients to participate in a research study of pituitary dysfunction.

Ages 18-55.

To Undergo Baseline Studies to Evaluate Consequences of Low Testosterone and To Receive Testosterone Replacement for 2 Months.

Subjects Will Be Compensated.

Contact:

Dr. Friedman or Dr. Zuckerbraun
Charles R. Drew University - Clinical Research Center
1731 E. 120th Street
Los Angeles, CA 90059
Telephone: 323-563-9353
Email: study@goodhormonehealth.com

More info.


Recruiting men with pituitary disease who have testosterone and growth hormone deficiencies.

Recruiting men with pituitary disease who have testosterone and growth hormone deficiencies.

Both testosterone and growth hormone individually improve bone density in men who have deficiencies of these hormones. The purpose of this research study is to determine if the combination of testosterone and growth hormone improves bone structure more than testosterone alone.

Thirteen outpatient visits over a 2-year period are required. Bone structure will be evaluated three times (at the beginning, after 12 months, and after 24 months). Three kinds of tests will be performed: DEXA, MRI and p-QCT. All three are non-invasive tests of bone quality and low risk.

By participating in this study you will learn more about the health of your bones and other aspects of your health. Reports will be provided to you and to any physician you wish. The study covers the cost of all study procedures and medications.

Study Criteria:

Contact:

Helen Peachey, RN, Research Coordinator
University of Pennsylvania Health System
Department of Endocrinology
778 Clinical Research Bldg.
415 Curie Blvd.
Philadelphia, PA 19104
Telephone: 215-898-5664
Fax: 215-573-5809
Email: peacheyh@mail.med.upenn.edu

Profile Page: University of Pennsylvania Health System, Philadelphia, PA

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