Saturday, March 22, 2008

Endo News

High prevalence of central adrenal insufficiency in patients with Prader-Willi syndrome

Strikingly, 60% of our PWS patients had central adrenal insufficiency. The high percentage of CAI in PWS patients might explain the high rate of sudden death in these patients, particularly during infection-related stress. Based on our data, one should consider treatment with hydrocortisone during acute illness in PWS patients, unless CAI has recently been ruled out with a metyrapone test...


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Journal of Clinical Endocrinology & Metabolism

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